Sargassum aquifolium juice prevents the increase in cholesterol levels and damage to the kidney profile in rat fed an atherogenic diet
Muhammad Harist Rifat Abdillah, Muhammad Firdaus

Brawijaya University

Abstract

Hypercholesterolemia is a condition in which cholesterol exceeds normal limits in the body. This condition can lead to necrosis of the kidneys. There are active ingredients that can prevent the rise in cholesterol levels. Sargassum aquifolium is a brown alga with bioactive content that can be used as a functional food to prevent elevated cholesterol levels. The content of active ingredients can be obtained by using the slow juicing method. This study aims to prevent cholesterol rise and kidney necrosis in rats. Rattus novergicus aged 2-3 months weigh about 150 g. Hypercholesterolemia was modelled by feeding a high-fat diet for six months. The phytochemical method was determined based on the Harborne method. Data were expressed ad mean and standard deviation. Experimental animals fed an atherogenic diet showed increases in cholesterol and MDA levels and renal necrosis. S. aquifolium juice given 2 times a day was able to prevent an increase in cholesterol levels and damage to the kidneys profile but was toxic when given 3 times a day. The conclusion was that S. aquifolium juice contains bioactive compounds that can prevent the increase in cholesterol levels and prevent damage to the kidney profile in rat fed an atherogenic diet

Keywords: S.aquifolium juice,functional food,phytochemical,hypercholesterolemia, kidney profile

Topic: Fisheries Product Technology and Food Safety (International)