Molecular docking analysis of selected natural products from Halymenias sp. and Laurencia sp seaweeds against Plasmepsins as antimalarials.
Asmi Citra Malina A.R Tasakka*1, Israini Wiyulanda Iskandar2 , Sulfahri3, Eko Agus Suyono4, Eko nurcahya dewi5, Mochammad Yuwono6, Kasmiati1 , Elmi Nurhaidah Zainuddin1, Marlina Achmad1, &#8234-Muhammad Iqbal Djawad1, Jamaluddin Fitrah Alam1&#8236-&#8236-, Widyastuti Umar&#8236-&#8236-1, and Andi Alya Yusriyyah2&#8236-&#8236-&#8236-&#8236-&#8236-&#8236-

1. Faculty of Marine Science and Fisheries, Universitas Hasanuddin, Makassar, South Sulawesi, Indonesia
2. Center for Excellence in Science and Technology of the Development and Utilization of Seaweed (PUI-P2RL)
3. Faculty of Mathematics and Natural Science, Universitas Hasanuddin, Makassar, South Sulawesi, Indonesia
4. Faculty of Biology, Universitas Gadjah Mada
5. Faculty of Fisheries and Marine Sciences, Diponegoro University
6. Faculty of Pharmacy, Airlangga University
*corresponding author : citra[at]unhas.ac.id

Abstract

Malaria is one of the most important public health problems worldwide, with nearly half of the global population exposed to the risk of contamination. The disease is found in 91 countries, mostly in the tropics and subtropics of the planet. There are several previous research that identifies Plasmepsins as a potential target to develop novel antimalarial drugs from the malaria parasite Plasmodium that play a role in the breakdown of globin into amino acids. Given the above, it is important to find novel and effective drugs that can decrease this disease, especially from natural products such as medicine. Seaweed is a potential source of bioactive compounds to be used as antimalarials such as species from the genera Laurencia and Halymenia. This recent study has studied the molecular docking approach to identify the potential of Halymenias sp. and Laurencia sp against Plasmepsin by using PyRx 0.8 software. It showed that the compounds in Halymenias sp. and Laurencia sp were able to react and inhibit the action of plasmepsin, seen from the binding affinity value which was quite small. ,3, this value is higher than the two bioactive compounds in seaweed, namely Stigmasterol and p-hydroxybenzaldehyde which have binding affinity values of -8.5 and 6.5, respectively. Judging from this, the compounds contained in Laurencia and Halymenia have potential as candidates for antimalarial drugs.

Keywords: Halymenias sp., Laurencia sp., Malaria, Natural Products, Plasmepsins

Topic: Marine and Fisheries Biotechnology (International)