The Potential Drug Interactions in Patients with Chronic Kidney Failure Stages 3,4 and 5 at X General Hospital Jakarta
Yardi Saibi, Vidia Arlaini Anwar, Suci Ahda Novitri

UIN Syarif Hidayatullah Jakarta (Yardi Saibi)
Stikes Ikifa Jakarta (Vidia Arlaini Anwar)
UIN Syarif Hidayatullah Jakarta (Suci Ahda Novitri))

Abstract

A drug interaction is said to occur when the effects of one drug are changed by the presence of another drug, herbal medicine, food, drink or by some environmental chemical agent. The incidence of drug interactions, both potential and actual, had been reported in a number of studies. The purpose of this study was to evaluate the potential for drug-drug interactions received by patients with chronic kidney failure stages 3, 4 and 5 at X general hospital in Jakarta. The samples were all patient medical records with chronic kidney failure stages 3,4 and 5 for the period January - December 2020. The data were collected retrospectively. Drug interaction checks were carried out using online interaction checkers and drug interaction reference books. Ethical clearance was obtained from the Health Research Ethics Commission, Faculty of Health Sciences UIN Syarif Hidayatullah Jakarta. The results showed that the patient characteristics were dominated by women as much as 52.5% with the highest age group in the range of 55-64 years at 41.3%. A total of 93.75% of patients received 5 or more types of drugs with anemia, hypertension and diabetes mellitus being the most common comorbidities. Potential drug interactions were found in 73.75% of the total 80 patients. Of the number of patients who hade potential drug interactions, there were 7 potential drug interactions with major and 64 moderate categories. Chronic renal failure patients who tend to receive polypharmacy have the potential for drug interactions. Pharmaceutical care in these patients needs to be given intensively.

Keywords: drug interaction, major, moderate, chronic kidney failure

Topic: Clinical Pharmacy