Tablet Formulation of Morinda citrifolia L. fruit Ethanolic Extract
Apriyani, Nurbaiti (a)*, Yuni Anggraeni (a) , Rizna Triana Dewi (b)

(a) Department of Pharmacy, Faculty of Health Sciences, Universitas Islam Syarif Hidayatullah Jakarta, Indonesia-
*nurbaiti.apriyani[at]mhs.uinjkt.ac.id
(b) Research Centre for Pharmaceutical Ingredient and Traditional Medicine, National Research and Innovation Agency (BRIN), Kawasan PUSPIPTEK, Building 452,
Serpong, Tangerang Selatan, Banten 15314 Indonesia

Abstract

Noni (Morinda citrifolia L.) is a tropical plants that has been used as a traditional medicine for hundred years by Polinesian people as an antihypertensive agent because it has bioactive compound such as scopoletin. Tablet is a dosage form that has many advantages such as easy to consume, has exact dose, and stable. The aim of this research were to determine the best consentration of microcapsules of Morinda citrifolia L. fruit ethanolic extract that meets the physical characteristics requirement of tablet. The tablet was made using dry granulation method because the extract has been in a powder form as a microcapsules of Morinda citrifolia L. fruit ethanolic extract, hygroscopic and has very poor flowability. The formulation is made into three formulas (F1, F2, F3) with various consentration of microcapsules of Morinda citrifolia L. fruit ethanolic extract (48%, 64%, and 80%). Physical characteristics tablet such as size and weight uniformity, friability, hardness, water content, and disintegration time has been evaluated using disintegration tester, friability tester, hardness tester, moisture balance, and disintegration tester. All formulas are capable to produced tablet dosage form that meets the physical characteristics requirements of tablet. Formula III tablets (contain 80% of Morinda citrifolia L. fruit ethanolic extract) produce the best physical characteristics with a weight of 625.405 mg, diameter 12.999 mm, thickness 3.75 mm, friability 0.49%, hardness 7.19 Kg, water content 4.47 %, and disintegration time 17.71 minutes. The concentration of microcapsules of Morinda citrifolia L. fruit ethanolic extract has an influence on the physical properties of granules and the physical properties of tablet preparations. The higher concentration of the extract, the higher friability and the shorter disintegration time of the tablet.

Keywords: Microcapsules- Morinda citrifolia L.- Tablet

Topic: Pharmaceutical Sciences