The Difference of Maternal Brain Derived Neurotrophic Factor and Total Score Edinburgh Postnatal Depression Scale Between Low and Normal Ferritin Among Pregnant Women Ayi Diah Damayani (a*), Eka Safitri Yanti (b)
a) Pusat Unggulan Institusi, Poltekkes Kemenkes Pangkalpinang, Bangka Belitung, Indonesia
*damayani.ayidiah[at]gmail.com
b) Pusat Unggulan Institusi, Poltekkes Kemenkes Pangkalpinang, Bangka Belitung, Indonesia
Abstract
Background and Objective Maternal iron deficiency anemia is thought to be related to postpartum depressive in biology pathway Ferritin is the first test to become abnormal as iron stores decrease and it is not affected by recent iron ingestion Furthermore, iron deficiency anemia also can decrease Brain Derived Neurotrophic Factor BDNF which play role in sinaps plasticity in neuron The purpose of this study is to determinate difference of maternal BDNF and total score Edinburgh Postnatal Depression Scale EPDS between low and normal ferritin among pregnant women Methods and Study Design This was an observational study with a cross sectional design at Health Center Care Lubuk Buaya Padang and Biomedical Laboratory Faculty of Medicine Andalas University in Indonesia in November 2016 to June 2017 Samples in this study are 72 pregnant women in 37 until 42 weeks pregnancy were divided to 2 groups which are low 12 ng/mL and normal ferritin 12 ngmL Ferritin and BDNF measured with ELISA after examination and EPDS were assessed at 2 weeks after delivery Data analysed using independent t test Result The average serum BDNF in low ferritin pregnant women was 3.32 3.95 ngmL and normal ferritin was 3.71 4.87 ngmL p 0,299. The average total score EPDS in low ferritin was 11,31 2,175 and normal ferritin was 6,69 3,104 p 0,000 Conclusion There was significant difference in total score EPDS but not serum BDNF between low and normal ferritin among pregnant women.
