The Effect of Bay Leaf Extract Gel on Fibroblasts in Traumatic Ulcers Healing Process Kurnia Nisa Putri Firawan (a), Ira Anggar Kusuma (a), Hermawan-Istiadi (b), Oedijani-Santoso (a)
(a) Dentistry Study Program, Faculty of Medicine, Universitas Diponegoro
(b) Departement of Anatomical Pathology, Faculty of Medicine, Universitas Diponegoro
Abstract
Traumatic ulcers are common lesion in the oral cavity. The healing process of traumatic ulcers consists of 4 phases, namely hemostasis, inflammation, proliferation, and remodeling phases. Fibroblast cells have an important role in wound healing process which appears on the 3rd day and reaches its peak on the 7th day after injury. Bay leaves contain compounds that have anti-inflammatory pharmacological. The research aims to determine the effect of bay leaf extract gel on fibroblasts cells in accelerating the ulcers healing process. The type of research is experimental research using post-test only control group design which consists of control group, treatment groups were given 5 percent and 10 percent of bay leaf extract gel with 5 samples of male Wistar rats on each group. The gel was applied twice a day until the 5th day. Labial mucosa in rats was observed using Hematoxylin Eosin staining to see fibroblast cells. Data analysis used one way Anova test and Post Hoc LSD test. The results show that the 10 percent of bay leaf extract gel treatment group is higher than the control goup and the 5 percent of bay leaf extract gel treatment group with a significant difference. The conclusion of this study is that bay leaf extract gel can increase of fibroblast cells in accelerating the ulcers healing process.
Keywords: bay leaf extract, traumatic ulcer, wound healing, fibroblast cell
