Mixed Formula of Red Bean Flour (Phaseolus vulgaris) and Breadfruit Flour (Artocarpus communis) on Blood Lipid Profile in Diabetes Rat Inducted Streptozotosin-Nicotynamide (STZ-NA) Mega Nurdini, Agus Wijanarka, Almira Sitasari
Poltekkes Kemenkes Yogyakarta
Abstract
Background: Diabetes Melitus (DM) is a chronic condition characterized by hyperglycemia. Severe and chronic DM conditions can effect fat metabolism causing dyslipidemia. This condition is characterized by an increase in total cholesterol, LDL, triglyceride levels, and a decrease in HDL levels. One of the efforts to reduce the risk of dyslipidemia in people with diabetes is to eat foods high in fiber and resistant starch, which are found in many plants, such as kidney beans and breadfruit. Processing of red beans and breadfruit into flour is also effective in increasing levels of fiber and resistant starch.
Research Purposes: To determine the effect of giving a mixture formula of red bean flour and breadfruit flour on changes in blood lipid profiles in diabetic rats induced by STZ-NA. Research Methods: This study used an experimental method with pre-test and post-test control group desaign in the Central Laboratory for Food and Nutrition Studies (PSPG) UGM Yogyakarta. The subjects of this study were 30 Spague Dawley rats, aged 2-3 months, and weighing 150-200 g. The rats were divided into 5 groups consisting of negative control group,positive control,intervention giving red been flour and breadfruit flour,with a dose of formula 1 (75%:25%),formula 2 (50%:50%), and formula 3 (25%:75%). Lipid profile levels were tested before and after the intervention for 21 days. The results of this study were analyzed using the One Way ANOVA test. Research Results: Based on the results of data analysis, there was a significant difference between the levels of lipid profiles (total cholesterol, LDL, HDL, and triglycerides) with the five experimental groups with p value of 0,000 (p<0,05). Furthermore, the paired t test pre test and post test for each experimental group showed a significant difference in lipid profile levels. Conclusions: The mixed formula of red been flour and breadfruit flour can be developed as a food alternative for DM patients who are accompanied by dyslipidemia.
Keywords: Red Been Flour, Breadfruit Flour, Lipid Profile, Diabetic Rats
