The influence of Pravastatin use to the level of Endhotelin 1 in high risk patients preeclampsia
Rizky A Ramadhani, Deviana Soraya Riu, Irnawati Bahar, Isharyah Sunarno, Eddy Hartono, Ny Retno B Farid

Obstetric and Gynecology Departement
Medical Faculty
Hasanuddin University
Makassar, Indonesia

Abstract

Objective: To determine the influence of Pravastatin use to Endotheline 1 levels in patients with high risk of preeclampsia

Method: 70 Research subjects consisting of 34 subjects with high risk of preeclampsia that get Aspirin and 36 research subjects get Aspirin and Pravastatin. The subject of the study was given therapy from the pregnancy age of 12 19 weeks 6 days to the age of pregnancy of 36 weeks. Then, the level of Endhotelin 1 before the administration of therapy compared with the level of endothelin 1 after administration of therapy.

Result: Test results showed the administration of aspirin and aspirin with pravastatin proved to provide significant changes in endothelin 1 levels after administration of therapy. It is characterized by decreased meaningful endothelin 1 levels (P < 0,005). However, by assessing the decrease in the percentage of aspirin with pravastatin , it provides greater changes in Endothelin 1 levels (45.74%) compared with the administration of aspirin alone (28.8%).

Keywords: high Risk patients preeclampsia, Aspirin, Pravastatin, Endothelin-1 levels

Topic: Maternal, neonatal, and child health