ANALYSIS OF TUMOR NECROSIS FACTOR ALPHA LEVEL IN IMMUNE THROMBOCYTOPENIA
Zahra Inayah Kasim (a), Rachmawati AM (b), Mansyur Arif (b)

(a)Clinical Pathology Specialist Program, Faculty of Medicine, Hasanuddin University, Makassar. Perintis Kemerdekaan KM 10 highway, Tamalanrea, Makassar, 90245. Indonesia.
zahra.pkunhas[at]gmail.com
(b)Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University, Makassar. Perintis Kemerdekaan KM 10 highway, Tamalanrea, Makassar, 90245. Indonesia.

Abstract

ABSTRACT
Objective : T Cell dysfunction in Immune Thrombocytopenia ( ITP) plays important role in the mechanism of loss of tolerance with impairment of cytokine balance. This research aims to analyse the TNF alpha level and its relation to thrombocytopenia in ITP patients.
Method : Using cross sectional method, this research was conducted in dr. Wahidin Sudirohusodo hospital, Makassar, on May until June of 2020. TNF alpha levels of 57 subjects diagnosed with ITP consisted of 32 primary and 25 secondary ITP were measured by Enzyme Linked Immunosorbent Assay (ELISA) method. Data were analysed statistically by Mann Whitney and Spearman test.
Result : The result showed a significantly higher TNF-&#945; level in primary ITP (396,7 nanogram per litres) compared to secondary ITP (124,2 nanogram per litres) (p<0,001). TNF alpha level correlate with the severity of thrombocytopenia in both groups (p< 0,05).
Conclusions : It was concluded that TNF alpha level was higher in primary ITP compared to secondary ITP and correlate with the severity of thrombocytopenia.

Keywords: Keywords : Immune Thrombocytopenia, TNF alpha, thrombocytopenia

Topic: Science, education, and women