The Dynamics of Interleukin-6 in Elderly Sarcopenia
Resliany, Agus Sudarso, Shanti Pricillia Makagiansar, Syakib Bakri, Haerani Rasyid, A Makbul Aman, Hasyim Kasim, and Arifin Seweng

Department of Internal Medicine, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Department of Biostatistics, Public Health Faculty, Hasanuddin University, Makassar,
Indonesia

E-mail : resliany1980[at]gmail.com

Abstract

Objective: This study aimed to know the dynamics of interleukin-6 (IL-6) in elderly sarcopenia .
Methods: This study was an analytic cross-sectional design conducted at the Geriatric Polyclinic of Wahidin Sudirohusodo Hospital, Makassar in March-June 2020. The assessed variables were degree of sarcopenia (probable sarcopenia, sarcopenia, dan severe sarcopenia) based on The European Working Group on Sarcopenia in Older People (EWGSOP2) criteria, age, sex, number of comorbids, and IL-6 levels examination.
Results: Studied of 82 subjects (51 females, 62.2%). Mean age 68.95 years. The prevalence of probable sarcopenia was 40.2%, sarcopenia 8.5%, severe sarcopenia 6.1%, and normal 45.1%. IL-6 levels were found to be significantly increased according to the severity of sarcopenia (normal, 52.81 ng/L; probable sarcopenia, 67.47 ng/L; sarcopenia, 135.36 ng/L; and severe sarcopenia, 287.99 ng/L). Based on age, IL-6 levels increased significantly with age (60-74 years, 63.28 ng/L; >/=75 years, 139.35 ng/L). Based on the number of comorbids, IL-6 levels increased significantly according to the number of comorbids (1-3 comorbids, 52.86 ng/L; >/= comorbids, 120.84 ng/L).
Conclusion: In the elderly subject, IL-6 levels increases according to the severity of sarcopenia. IL-6 levels also increases with age, and the number of comorbids.

Keywords: Sarcopenia, IL-6, Elderly.

Topic: Non-communicable diseases related to women