Self-Nanoemulsifying Formulation of Kencur (Kaempferia galanga L.) Rhizome Extract with Variation of Tween 80 and PEG 400 Beti Pudyastuti (a*), Agatha Budi Susiana Lestari (b)
a) Department of Pharmacy, Jenderal Soedirman University, Indonesia
*betipudyastuti[at]unsoed.ac.id
b) Faculty of Pharmacy, Sanata Dharma University, Indonesia
Abstract
Background: Kencur (Kaempferia galanga L.) rhizome contains ethyl p-methoxy cinnamate (EPMS) compound. EPMS, a lipophilic compound of Kencur rhizome, can be formulated in a self-nano emulsifying drug delivery system (SNEDDS).
Purpose: To determine the effect of Tween 80 and PEG 400 on increasing the solubility of kencur rhizome extract.
Methods: The SNEDDS formulations were carried out by optimizing the amount of Tween 80-PEG 400 as surfactant-cosurfactant with Virgin Coconut Oil (VCO) as the oil phase. The solubility, particle size, transmittance, and emulsification time were evaluated as responses to determine the increasing effect in extract solubility. The stability test was conducted in artificial intestinal fluid and artificial gastric fluid for 4 hours.
Results: The study found that the ratio of Tween 80:PEG 400 (3:1) and VCO on 6:1 as an optimum formula could produce homogenous clear SNEDDS with particle size 18.6 nm, transmittance 95.63%, emulsified rapidly between 32-36 seconds, and stable for 4 hours.
Conclusion: The optimum formula of SNEDDS could increase the solubility of kencur rhizome extract 340 times compared to extract in water.
