Annona muricata Leaves Ethanolic Extract Increases p53 Expression in Rats Breast Cancer
Eka Prasasti Nur Rachmani (a), Evy Sulistyoningrum (b), Hanif Nasiatul Baroroh (a), Fitri Aprilia Junaedi (a)

(a) Pharmacy Department, Jenderal Soedirman University, Purwokerto, Jawa Tengah, Indonesia
(b) Medicine Faculty, Indonesian Islamic University, Yogyakarta, Indonesia

Abstract

Annona muricata Linn. (soursop) leaves contains acetogenin which have cytotoxic effect on cancer cell lines. The study was aimed to examine soursop leaves ethanolic extract on increases p53 expression in 7,12 Dimethylbenz [a]anthracene (DMBA) induced Sprague Dawley rats. The induction DMBA was done twice a week for five weeks. Ten days after DMBA induction, the rat s breast cancer were given soursop leaves ethanolic extract in four doses 200, 300, 400 and 500 mg/kgBW everyday for two weeks. Tamoxifen was given in positive control group. The result showed that soursop leaves ethanolic extract could increase p53 protein expression effectivelly in dose 400 mg/kgBW.

Keywords: Annona muricata ethanolict extract, p53, breast cancer, 7,12-Dimethylbenz[a] anthracene (DMBA)

Topic: Pharmacy