LYCOPENE IN TOMATO AS ANTI NEPHROTOXIC AND ANTIINFLAMMATORY IN WELDING WORKERS EXPOSED TO CADMIUM
Hernayanti, Sri Lestari, Saryono

Hernayanti, Sri Lestari Faculty of Biology Unsoed
Saryono , Faculty of Health Science Unsoed

Abstract

Lycopene in tomatoes is a potential antioxidant because it can reduce free radical compounds that enter the body. The power of lycopene in reducing free radicals is 20 times greater than vitamin C and 10 times greater than vitamin E. The aim of this study were to know the effect of administration tomato powder as anti nephrotoxic and anti inflammatory on welding workers exposed by Cd. This research use observational analytical with cross-sectional design. Research subject consisted of 30 welding workers in Purwokerto aged 25-55 years with a work period more than 3 years. Welding workers were given tomato powder at a dose of 30 g for consumption for 14 days. On the 0th and 15th day, blood was taken to examine kidney function and inflammatory parameters. These data analyzed by paired t-test. The results showed blood Cd levels, Metallotionein, Creatinine, β2-microglobuline, Tumor Necrosis Factor-α and Cyclooxygenase-2 levels after being given tomato powder were very significant difference compare to before given tomatoes . It can be concluded that the administration of tomato powder has an effect on improving kidney function. Tomatoes powder decrease in both blood Cd levels and pro inflammatory cytokines in welding workers exposed by Cd.

Keywords: Cadmium, metallothionein, antinephrotoxic, antiinflammatory

Topic: Biomedical Sciences