Wound Healing Process with Kersen Leaf Extract Gel on the Macrophage, Fibroblast and Osteoblast Number in the Wistar Rats after Tooth Extraction
Miftakhul Cahyati*

Department of Oral Medicine, Faculty of Dentistry, Universitas Brawijaya, Malang, East Java, Indonesia
Corresponding author : miftacahyati.fk[at]ub.ac.id

Abstract

Tooth extraction causes damage to soft and hard tissue. The kersen leaf Muntingia calabura l. extract gel containing flavonoids, tannins dan saponins that it can increase the number of macrophages, fibroblast and osteoblast which will migrate to the wound area then wound healing will be fast. This research aimed to know the influence of the kersen leaf extract gel. toward the number of tooth extraction macrophages, fibroblast and osteoblast in wound healing process of Wistar rat. The research method used was true experimental using the Post Test Only Randomized Control Design Group in Wistar rat. The sample was split randomly and divided into 6 groups, the control groups who were not given the kersen leaf extract gel and the treatment groups was given a kersen leaf extract gel and was decaputated in day 3rd, 5th, and 7th. Hard tooth tissue was taken and Hematoxylin Eosin staining. The results of the independent t test showed a significant difference between the control group and the treatment group p <0.05. Macrophages at 3rd day, fibroblast at 3rd day and osteoclast at 7th day. The conclusions of research on the kersen leaf extract gel have an effect on the amount of tooth extraction macrophages, fibroblast and osteoblast of Wistar rat.

Keywords: Kersen, Macrophages, Fibroblast, Osteoclast, Tooth Extraction

Topic: HEALTH, NUTRITION AND MEDICAL MICROBIOLOGY