Formulation of Anti-acne Cream Bawang Dayak Ethanol Extract (Eleutherine bulbosa (Mill.) Urb.)
Susi Novaryatiin*, Astri Ayu Agustin, Syahrida Dian Ardhany

Department of Pharmacy, Faculty of Health Sciences, Universitas Muhammadiyah Palangkaraya, Jl. RTA Milono Km. 1,5 Palangka Raya 73111, Indonesia
*susi_novaryatiin[at]yahoo.com

Abstract

Bawang dayak (Eleutherine bulbosa (Mill.) Urb.) is a typical plant of Central Kalimantan. In the previous studies, it was known that bawang dayak ethanol extract can inhibit Propionibacterium acnes, and was made in the cream formulation to improve the efficiency of using traditional medicine. This study was aimed to determine the effect of bawang dayak cream storage for 30 days on physical properties and antibacterial activity compared to the preliminary studies conducted on the cream on days 0 and 7. Four formulas of cream were made by a variation of bawang dayak ethanol extract. F1 5%, F2 10%, F3 15%, and F4 20%. Then evaluated by organoleptic, homogeneity, pH, adhesion, and dispersion test. Cream potential as anti-acne was determined by antibacterial activity test against Propionibacterium acnes, using a disc-diffusion technique. The results showed that F3 dan F4 cream meets the requirements for pH, adhesion, and dispersion test, but not homogenous. The adhesion time in this study was better than the formula on day 7. All cream formula on the 30 days of storage showed weak activity against Propionibacterium acnes. This present study showed the potential of all formula as anti-acne cream but further research needed to improved formula composition and stability so it can be developed as an anti-acne cream product.

Keywords: Anti-acne cream; Bawang dayak: Propionibacterium acnes; Physical properties

Topic: Health, Medical, Pharmacy and Technology